Corvalen® D-ribose,
is a natural pentose sugar that is designed for the support of cardiovascular health, fatigue, energy
production, and mitochondrial function†. This slightly sweet d-ribose powder is rapidly dissolved and
readily absorbed into the body.
Corvalen® contains pure D-ribose, a safe and clinically researched ingredient that supports the natural way
our bodies produce adenosine triphosphate (ATP), the energy currency of the cell. Ribose is the vital structural
backbone of critical cellular compounds called purines and pyrimidines. Our bodies must have an adequate
supply of purines and pyrimidines to form major cellular constituents such as our genetic material (DNA and
RNA), numerous cofactors, certain vitamins, and, importantly, adenosine triphosphate (ATP). Ribose is the
starting point for the synthesis of these fundamental cellular compounds, and the availability of ribose
determines the rate at which they can be made by our cells and tissues.D-ribose is a structural component of
DNA, RNA, ATP, GTP, flavins (FAD, riboflavin) and other important nucleotides found in all living cells.
Ribose
is formed naturally via the pentose phosphate pathway. This pathway is slow and rate-limited in cardiac and
skeletal muscle due to an inherently low concentration (lack of expression) of the enzymes, glucose-6-
phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. The product of this pathway is ribose-5-
phosphate, which in turn is converted to 5-phosphoribosyl-1-pyrophosphate (PRPP), the primary driver in the
synthesis and salvage of purine nucleotides. No other compound can be used by the body for this metabolic
purpose. Purine nucleotides (ATP and its precursors) lost due to ischemia, hypoxia, or genetic predisposition
are replaced via the purine nucleotide pathway. This pathway is rate limited by the availability of ribose in
tissue. Administration of exogenous ribose bypasses the rate-limiting steps in the pentose phosphate pathway,
resulting in a significant acceleration of PRPP.
Renewed concentration of ATP is accompanied by an increased energy potential in the cell, also known as the
“energy charge.” Cardiac and skeletal muscle functions (i.e. contraction, cell wall maintenance, relaxation,
polarization of the cell membrane) each require a different, quantifiable energy charge to drive or provide
allosteric regulation for each function. Restoration of cellular energy charge restores function consistent with
the degree of energy charge restored.
D-ribose is indicated for sports and fitness activities because it helps to reduce the loss of energy during stress
and accelerate energy and tissue/muscle recovery†. Endurance athletes and strength training athletes will
both benefit from the effects of supplemental D-ribose.
Unless our hearts have an adequate supply of ribose, they simply cannot satisfy their astonishing energy
demand. Our bodies make ribose naturally, but in times of stress the need is greater than our supply to satisfy
the loss of energy from our cells. That is why supplementing with d-ribose can support proper heart function
and helps maintain healthy stroke volume during and after high intensity exercise. One of the original studies
performed by Schneider et al in 1985 found that supplementation with D-ribose after cardiac ischemia resulted
in a significant shorter duration of diastolic recovery time vs. the control group (2.8 days vs. 9.4 days). Another
study by Olman et al in 2003 showed beneficial effects on diastolic function and quality of life in compromised
patients after only 3 weeks of supplemental D-ribose.
Although D-ribose is a five-carbon monosaccharide, it does not raise blood sugar.
Corvalen® D-ribose is highly soluble in both hot or cold solutions and tastes slightly sweet. Corvalen® Dribose
is non-GMO. D-ribose is rapidly and readily (~95%) absorbed with peak blood levels found within 30 –
45 minutes. Ribose not taken up by the cell is excreted unchanged in the urine. Corvalen® D-ribose is GRAS
(generally recognized as safe), a determination that results only after considerable toxicology studies are
performed and an expensive and time consuming FDA process is completed.
Corvalen® is an all-natural D-ribose clinically proven to help restore energy, support cardiac function and
reduce muscle stiffness, soreness, and fatigue.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
This product was added to our catalog on Wednesday 28 May, 2014.